Lesley Curtis PhD

Lesley Curtis Headshot

Core Faculty

Lesley Curtis, PhD


PhD, University of Rochester

Dr. Curtis is a health services researcher who oversees a portfolio of projects that use observational data to address questions related to clinical and comparative effectiveness, pharmacoepidemiology, health care delivery, and epidemiological trends across a broad array of clinical conditions and clinical care settings. An expert in the use of Medicare claims data for health services and clinical outcomes research, she has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study. 

Dr Curtis directs the Center for Pragmatic Health Systems Research at the Duke Clinical Research Institute and leads the Distributed Research Network Operations Center for PCORI’s National Clinical Research Network (PCORnet), working with health systems and patient networks to develop a harmonized data infrastructure for robust observational and interventional research.

Areas of expertise: Health Services Research and Health Policy

Randell RL, Hornik CP, Curtis L, Hernandez AF, Denwood T, Nebeker C, et al. "Click and mortar" opportunities for digitization and consumerism in trials. Contemp Clin Trials. 2023 Sep;132:107304.

Pomann G-M, Truong T, Boulos M, Ebony Boulware L, Brouwer RN, Curtis LH, et al. Needles in a Haystack: Finding Qualitative and Quantitative Collaborators in Academic Medical Centers. Acad Med. 2023 Aug 1;98(8):889–95.

Sola-Morales O, Curtis LH, Heidt J, Walsh L, Casso D, Oliveria S, et al. Effectively Leveraging RWD for External Controls: A Systematic Literature Review of Regulatory and HTA Decisions. Clin Pharmacol Ther. 2023 Aug;114(2):325–55.