Lesley Curtis Headshot

Core Faculty

Lesley Curtis, PhD

Contact

lesley.curtis@duke.edu

Focus Areas
Degree

PhD, University of Rochester

Dr. Curtis is a health services researcher who oversees a portfolio of projects that use observational data to address questions related to clinical and comparative effectiveness, pharmacoepidemiology, health care delivery, and epidemiological trends across a broad array of clinical conditions and clinical care settings. An expert in the use of Medicare claims data for health services and clinical outcomes research, she has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study. 

Dr Curtis directs the Center for Pragmatic Health Systems Research at the Duke Clinical Research Institute and leads the Distributed Research Network Operations Center for PCORI’s National Clinical Research Network (PCORnet), working with health systems and patient networks to develop a harmonized data infrastructure for robust observational and interventional research.

Areas of expertise: Health Services Research and Health Policy

From Scholars@Duke

Scholars@Duke Profile
Harrington J, Reddy RK, Carnicelli A, Wilson L, Lopes RD, Gersh BJ, et al. Medicare coverage gap status, adherence to oral anticoagulation, and stroke rates in patients with atrial fibrillation. Am Heart J. 2026 Jan;291:63–72.

Dupre ME, Dhingra R, Xu H, Hammill BG, Lynch SM, West JS, et al. Racial and ethnic disparities in longitudinal trajectories of hospitalizations in patients diagnosed with heart failure. Am Heart J. 2025 Sep;287:32–40.

Abbasi AB, Curtis LH, Califf RM. The Promise of Real-World Data for Research - What Are We Missing? N Engl J Med. 2025 Jul 24;393(4):318–21.