Lesley Curtis PhD

Lesley Curtis

Core Faculty

Lesley Curtis, PhD


PhD, University of Rochester

Dr. Curtis is a health services researcher who oversees a portfolio of projects that use observational data to address questions related to clinical and comparative effectiveness, pharmacoepidemiology, health care delivery, and epidemiological trends across a broad array of clinical conditions and clinical care settings. An expert in the use of Medicare claims data for health services and clinical outcomes research, she has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study. 

Dr Curtis directs the Center for Pragmatic Health Systems Research at the Duke Clinical Research Institute and leads the Distributed Research Network Operations Center for PCORI’s National Clinical Research Network (PCORnet), working with health systems and patient networks to develop a harmonized data infrastructure for robust observational and interventional research.

Areas of expertise: Health Services Research and Health Policy

Raman SR, O’Brien EC, Hammill BG, Nelson AJ, Fish LJ, Curtis LH, et al. Evaluating fitness-for-use of electronic health records in pragmatic clinical trials: reported practices and recommendations. J Am Med Inform Assoc. 2022 Apr 13;29(5):798–804.

Kelsey MD, Patrick-Lake B, Abdulai R, Broedl UC, Brown A, Cohn E, et al. Inclusion and diversity in clinical trials: Actionable steps to drive lasting change. Contemp Clin Trials. 2022 Mar 29;116:106740.

Weissler EH, Ford CB, Narcisse DI, Lippmann SJ, Smerek MM, Greiner MA, et al. Clinician Specialty, Access to Care, and Outcomes Among Patients with Peripheral Artery Disease. Am J Med. 2022 Feb;135(2):219–27.