Lesley Curtis PhD

Lesley Curtis

Core Faculty

Lesley Curtis, PhD


PhD, University of Rochester

Dr. Curtis is a health services researcher who oversees a portfolio of projects that use observational data to address questions related to clinical and comparative effectiveness, pharmacoepidemiology, health care delivery, and epidemiological trends across a broad array of clinical conditions and clinical care settings. An expert in the use of Medicare claims data for health services and clinical outcomes research, she has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study. 

Dr Curtis directs the Center for Pragmatic Health Systems Research at the Duke Clinical Research Institute and leads the Distributed Research Network Operations Center for PCORI’s National Clinical Research Network (PCORnet), working with health systems and patient networks to develop a harmonized data infrastructure for robust observational and interventional research.

Areas of expertise: Health Services Research and Health Policy

Weissler EH, Naumann T, Andersson T, Ranganath R, Elemento O, Luo Y, et al. Correction to: The role of machine learning in clinical research: transforming the future of evidence generation. Trials. 2021 Sep 6;22(1):593.

Narcisse DI, Ford CB, Weissler EH, Lippmann SJ, Smerek MM, Greiner MA, et al. The association of healthcare disparities and patient-specific factors on clinical outcomes in peripheral artery disease. American Heart Journal. 2021 Sep;239:135–46.

Curtis LH, Hoffman MN, Califf RM, Hammill BG. Life expectancy and voting patterns in the 2020 U.S. presidential election. Ssm Popul Health. 2021 Sep;15:100840.