Lesley Curtis PhD

Lesley Curtis Headshot

Core Faculty

Lesley Curtis, PhD


PhD, University of Rochester

Dr. Curtis is a health services researcher who oversees a portfolio of projects that use observational data to address questions related to clinical and comparative effectiveness, pharmacoepidemiology, health care delivery, and epidemiological trends across a broad array of clinical conditions and clinical care settings. An expert in the use of Medicare claims data for health services and clinical outcomes research, she has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study. 

Dr Curtis directs the Center for Pragmatic Health Systems Research at the Duke Clinical Research Institute and leads the Distributed Research Network Operations Center for PCORI’s National Clinical Research Network (PCORnet), working with health systems and patient networks to develop a harmonized data infrastructure for robust observational and interventional research.

Areas of expertise: Health Services Research and Health Policy

O’Brien EC, Mulder H, Jones WS, Hammill BG, Sharlow A, Hernandez AF, et al. Concordance Between Patient-Reported Health Data and Electronic Health Data in the ADAPTABLE Trial. Jama Cardiol. 2022 Dec 1;7(12):1235–43.

Hammill BG, Leimberger JD, Lampron Z, Raman SR, O’Brien EC, Wurst KE, et al. Fitness of real-world data for clinical trial data collection: Results and lessons from a HARMONY Outcomes ancillary study. Clin Trials. 2022 Dec;19(6):655–64.

O’Brien EC, Sugarman J, Weinfurt KP, Larson EB, Heagerty PJ, Hernandez AF, et al. The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory. Trials. 2022 May 21;23(1):424.