Dr. Curtis is a health services researcher who oversees a portfolio of projects that use observational data to address questions related to clinical and comparative effectiveness, pharmacoepidemiology, health care delivery, and epidemiological trends across a broad array of clinical conditions and clinical care settings. An expert in the use of Medicare claims data for health services and clinical outcomes research, she has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study.
Dr Curtis directs the Center for Pragmatic Health Systems Research at the Duke Clinical Research Institute and leads the Distributed Research Network Operations Center for PCORI’s National Clinical Research Network (PCORnet), working with health systems and patient networks to develop a harmonized data infrastructure for robust observational and interventional research.
Areas of expertise: Health Services Research and Health Policy
Califf RM, Curtis LH, Harrington RA, Hernandez AF, Peterson ED. Generating evidence for therapeutic effects: the need for well-conducted randomized trials. J Clin Invest. 2021 Jan 19;131(2).
Lentz TA, Curtis LH, Rockhold FW, Martin D, Andersson TLG, Arias C, et al. Designing, Conducting, Monitoring, and Analyzing Data from Pragmatic Randomized Clinical Trials: Proceedings from a Multi-stakeholder Think Tank Meeting. Ther Innov Regul Sci. 2020 Nov;54(6):1477–88.
Stevens LM, Mortazavi BJ, Deo RC, Curtis L, Kao DP. Recommendations for Reporting Machine Learning Analyses in Clinical Research. Circ Cardiovasc Qual Outcomes. 2020 Oct;13(10):e006556.